Treatment-Resistant OCD? Ketamine Is Among the Few Things That Can Acutely Reduce Obsessions Within Hours.
At-home ketamine therapy paired with Exposure and Response Prevention (ERP) — prescribed by Dr. David Mahjoubi, MD board-certified anesthesiologist and author of The Art & Science of Ketamine Medicine. Backed by Columbia University and recent peer-reviewed research on glutamate-system modulation in OCD. First 30-day supply covered.
- 3,900+ patients since 2014
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From Booking to Better in One Week
How Quickly You Could Feel Better
Most patients with depression, anxiety, or PTSD don’t have time to wait six weeks for a medication to maybe work. Here’s how fast the NutraBrain protocol can move.
Today
Book Your Consult
Complete a brief intake form online — takes about 5 minutes.
24–48 hrs
Meet Dr. Mahjoubi
Your private video consultation, scheduled within one to two days.
1–2 days later
Ketamine Arrives
Your personalized prescription shipped from a licensed U.S. compounding pharmacy.
1 week from today
Start Feeling Better
Most patients report meaningful shifts in mood, calm, or clarity within the first week of treatment.
Individual results vary. Most patients report noticeable improvements within 1–14 days.
If any of this sounds like you, you’re in the right place.
- Intrusive thoughts that you can’t shut off — contamination, harm, religious, “just right,” or pure obsessional.
- Rituals that eat hours of your day. Showering, checking, counting, mental review, reassurance-seeking.
- You’ve tried two or more SSRIs at high doses for at least 12 weeks each — and they barely moved the dial.
- You’ve started ERP and the anxiety was so high you couldn’t push through.
- Your obsessions are so constant you can’t get traction on anything else in your life.
- You’re functional on the outside but exhausted from holding your OCD together every minute.
OCD isn’t just willpower — it’s a glutamate-system problem.
Research over the past decade has shifted away from the older “serotonin-only” model of OCD. The cortico-striato-thalamo-cortical (CSTC) loop that’s overactive in OCD is regulated by glutamate. Ketamine is an NMDA receptor antagonist — it modulates that loop directly and rapidly, in a way SSRIs cannot.
The Research: What the Peer-Reviewed Studies Actually Show
The evidence base for ketamine in OCD is smaller than for depression — but it is real, peer-reviewed, and growing.
Neuropsychopharmacology · 2013 (the landmark study)
Randomized Controlled Crossover Trial of Ketamine in Obsessive-Compulsive Disorder: Proof-of-Concept
Rodriguez CI, Kegeles LS, Levinson A, Feng T, Marcus SM, Vermes D, Flood P, Simpson HB — Columbia University / New York State Psychiatric Institute
Journal of Anxiety Disorders · 2016
Can Exposure-Based CBT Extend the Effects of Intravenous Ketamine in Obsessive-Compulsive Disorder? An Open-Label Trial
Rodriguez CI, Wheaton M, Zwerling J, Steinman SA, Sonnenfeld D, Galfalvy H, Simpson HB
CNS Spectrums · 2024 (systematic review & meta-analysis)
Ketamine for the Treatment of Psychiatric Disorders: A Systematic Review and Meta-Analysis
Recent pooled analysis of OCD and other indications
Journal of Psychopharmacology · 2025
Ketamine for Treatment-Resistant Obsessive-Compulsive Disorder: Double-Blind Active-Controlled Crossover Study
Beaglehole B, Glue P, Neehoff S, Shadli S, McNaughton N, et al. — University of Otago, New Zealand
Pharmaceuticals (MDPI) · 2026 (scoping review)
Ketamine and Esketamine in Obsessive–Compulsive Disorder: A Scoping Review of Clinical and Mechanistic Evidence
Recent comprehensive scoping review
Ketamine is FDA-approved as an anesthetic and (as esketamine) for treatment-resistant depression. Its use for OCD is off-label and supported by the studies above. The evidence base is smaller than for depression — NutraBrain is transparent about that.
Two ways to pay — pick the one that fits your treatment.
Simple, Transparent Pricing
No hidden fees, no insurance runaround, no surprise bills. Your first 30-day supply of medication is included. After that, what you pay depends on how often you need refills.
Monthly Care
For patients on an active, ongoing protocol
$400 to start
One-time initial consultation + first prescription
$69 / month after that
Ongoing physician care & monthly refills
- Initial video consult with Dr. Mahjoubi
- First 30-day medication supply included
- Monthly refills shipped to your door
- Continuous physician oversight & dose adjustments
As-Needed Care
For patients who don’t refill every month
$400 every 3–4 months
Consultation + prescription, only when you need it
- Video consult with Dr. Mahjoubi each visit
- A fresh prescription supply each visit
- No monthly fee between visits
- Ideal for maintenance or occasional dosing
What the $400 covers
The consultation
A private video visit with Dr. Mahjoubi to review your history and design your protocol.
The prescription
Your personalized medication, shipped from a licensed U.S. compounding pharmacy.
The $69/mo (optional)
Only applies if you choose monthly refills — it covers the doctor’s ongoing care between consults.
Not sure which path fits? Book a free consult and Dr. Mahjoubi will recommend the right approach for your OCD treatment. Pricing shown is for NutraBrain’s at-home ketamine program and does not include optional ERP therapy with an outside provider.
The Honest Reality: Ketamine Alone Doesn't Cure OCD
We want you to make an informed decision, so here’s what the literature actually shows about how long the effects last and what makes them stick.
The Missing Piece: ERP Therapy Alongside Ketamine
Exposure and Response Prevention (ERP) is the gold-standard behavioral treatment for OCD — endorsed by the American Psychiatric Association and the International OCD Foundation. It teaches your brain that obsessions can be tolerated without rituals. Ketamine quiets the anxiety enough for ERP to land.
If you already have an ERP therapist
Great — Dr. Mahjoubi will coordinate with them when you give consent, so your ketamine sessions are scheduled to optimize the window your therapist works in.
If you don’t yet have an ERP therapist
Find one. ERP-trained therapists are different from general CBT therapists — make sure they specifically practice ERP for OCD. Most are in-person or telehealth via Zoom.
Where to find an ERP therapist
The International OCD Foundation maintains the most comprehensive directory of ERP-trained providers in the U.S. It’s free to use and filterable by state, telehealth, and insurance.
What if I can’t afford ERP?
Several lower-cost options exist: NOCD offers telehealth ERP with many insurance plans accepted. University training clinics offer reduced-fee ERP with supervised therapists-in-training. Dr. Mahjoubi can help you think through options during your consult.
Use the IOCDF provider directory to find an ERP therapist near you:
Book Your Free Consult with Dr. Mahjoubi
Tell us a little about your situation and Dr. Mahjoubi’s team will reach out within 24 hours to schedule your consult. No credit card required.
Who Ketamine + ERP Is Right For
- Adults with diagnosed OCD or treatment-resistant OCD (typically ≥2 SSRIs at maximum tolerated dose for ≥12 weeks each, without sufficient response).
- Patients willing to engage with ERP — either with their existing therapist or a new ERP-trained provider.
- Patients who can tolerate brief dissociative effects — Dr. Mahjoubi will discuss this carefully during your consult, since the experience matters more for OCD than for most other conditions.
- OCD subtypes the literature supports response in: contamination, harm, “just right” / symmetry, religious/scrupulosity, sexual orientation OCD, relationship OCD, pure obsessional (“Pure O”), checking.
Who Ketamine + ERP Is NOT Right For
- OCD where loss of control over your mind is the primary fear. The 2025 Beaglehole study identified this as a real tolerability problem. If you’d find the dissociative experience of ketamine itself catastrophic rather than benign, this is the wrong tool. Dr. Mahjoubi will screen for this during your consult.
- Active psychosis, schizophrenia, schizoaffective disorder, or severe dissociative disorders.
- Uncontrolled substance use disorder.
- Severe bipolar disorder in an active manic episode.
- Certain cardiac conditions (uncontrolled hypertension, recent cardiac event) — Dr. Mahjoubi will screen.
- Patients unwilling to engage with ERP or behavioral support. Ketamine alone is unlikely to produce sustained benefit in OCD — NutraBrain wants to be honest about this rather than take your money for a treatment that’s unlikely to stick.
- Pediatric OCD. Ketamine for OCD in patients under 18 is not supported by current literature.
Why OCD Patients Who Are Ready for ERP Choose NutraBrain
Ketamine isn’t a stand-alone cure. But it can unlock the work that produces lasting OCD recovery.
Acute Reduction Within Hours
The published literature shows obsessions can reduce within hours of dosing — opening a window where the work of ERP becomes possible.
An Anesthesiologist, Not a Platform
Dr. Mahjoubi is a board-certified anesthesiologist with 17 years of ketamine experience. For OCD especially, careful dosing matters — and he literally wrote the manual on it.
Designed Around ERP, Not Without It
NutraBrain’s OCD protocol is built to pair with your ERP therapist. Dr. Mahjoubi coordinates timing of doses with your ERP sessions when you give consent.
Lower Starting Doses for OCD
Following the 2025 Beaglehole guidance, Dr. Mahjoubi starts OCD patients at lower doses and titrates up. Less dissociation, more control. Critical for this audience.
First Prescription On Us
Your first 30-day supply is covered. Try it, see how you tolerate it, see if the ERP window opens — before committing.
Research-Forward, Not Hype-Driven
The evidence base for ketamine + OCD is smaller than for depression. We’re transparent about that — and we cite the actual peer-reviewed studies right on this page.
Why people switch to NutraBrain from other telehealth ketamine programs
Monthly cost, dosing ceiling, and medication flexibility compared.
| Provider | Monthly | Dose Ceiling | Medication Forms |
|---|---|---|---|
| NutraBrain | $69/mo | Up to 1,400 mg/week | Any form · sessions or microdose |
| Joyous | $129/mo | Low dose | Troches only |
| BetterU | ~$264/mo | Limited (9-session package) | Troches only |
| Mindbloom | ~$358/mo | Capped dose, bi-weekly | RDT + SubQ only |
| Innerwell | ~$366/mo | Up to 800 mg/session | RDT only · ~1× weekly |
| Wondermed | $399/mo | 1–2× weekly sessions | Troches only |
Pricing for other providers is based on publicly available information as of March 2026 and is subject to change. Most other programs don’t treat alcohol or cannabis use disorder at all. Actual costs vary by treatment plan, clinical assessment, dosage, frequency, and geographic location. NutraBrain Clinic is not affiliated with any companies referenced. This is not medical advice and does not guarantee clinical outcomes.
What ketamine + ERP looks like for OCD patients
Honest framing: the ketamine “window” is short. The ERP is what makes it stick.
Hours 1–24
The Window Opens
Within hours of your first dose, many patients report a softening of obsessions — a quieter mind, less compulsive pull. This is the neuroplasticity window the research describes.
Days 1–7
The Window Is Used
Your ERP therapist works inside this window — running exposures that were previously too anxiety-provoking to tolerate. The gains here are what consolidate into long-term change.
Weeks 2+
Maintenance + Consolidation
Dr. Mahjoubi schedules ongoing maintenance doses paired with continued ERP. Over weeks to months, many patients can space doses out and rely increasingly on the behavioral gains they’ve built.
From patients who've worked the program
We’re transparent: we’re actively gathering verified, written-consent testimonials from OCD patients. Below are example narratives of the kind of experience the research and our clinical practice describes — they will be replaced with real, verified patient stories.
5 Stars“Would highly recommend Dr. Mahjoubi for the treatment and management of chronic/severe pain and mood disorders.“Neesh L.Yelp
5 Stars“Dr Mahjoubi is one of the most amazing physicians I have had the honor of having help me. His caring demeanor, vast array of capacities into which he tries to place himself when relating to a patient and wealth of medical knowledge is not only impressive but palpable during consultations. If you take a second to peruse his publications its quite easy to see that his educational history is not only to be found in the formative Med School/Academic times of his life, but within the time of his practicing as well.“Zane C. Y.

You'll be treated by an anesthesiologist who wrote the book on ketamine medicine — literally.
Dr. David Mahjoubi, MD is a board-certified anesthesiologist with over 17 years in ketamine therapy. He is the sole author of The Art & Science of Ketamine Medicine — the only physician-authored ketamine treatment manual in print — and serves as President of the American Board of Ketamine Physicians..
For OCD specifically, careful dose titration and pairing with ERP matter more than for almost any other indication. Dr. Mahjoubi follows the dose guidance from the 2025 Beaglehole study, screens for dissociation tolerance during the consult, and coordinates with your ERP therapist when you give consent.
- Board-Certified Anesthesiologist
- Ketamine Prescriber Since 2014
- President, American Board of Ketamine Physicians
- Founder, Ketamine Healing Clinic of Los Angeles (2014)
- Author, The Art & Science of Ketamine Medicine
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How the NutraBrain Program Works
1
Complete Intake + Book Consult
Book your free video consultation with Dr. David Mahjoubi.
2
Receive Medication by Mail
Your personalized prescription ships discreetly to your door. Begin treatment under Dr. Mahjoubi’s guidance.
3
Enroll in $69/mo Membership
Continue with ongoing refills and unlimited email access — or don’t. No long-term contract.
Try the first month on us.
Your first 30-day ketamine supply is covered when you book your initial consult. If after that first month — paired with your ERP work — you don’t feel a meaningful difference, you don’t continue. No contracts. No auto-billing. No commitment beyond your initial consult fee.
Or call (818) 570-1640 — Jackie, our patient coordinator, can answer questions.
Common questions from OCD patients
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No. Ketamine is FDA-approved as an anesthetic and (as esketamine / Spravato) for treatment-resistant depression. Its use for OCD is considered off-label. The evidence base — Rodriguez 2013, Rodriguez 2016, the 2024 meta-analysis, Beaglehole 2025, and the 2026 scoping review — supports a clinically meaningful effect, but the FDA has not formally approved it for OCD.
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Acute effects from a single dose typically last about one week. This is the central reason ERP is essential — ERP turns the short ketamine window into long-term behavioral change. Many patients move to maintenance dosing over months as their ERP gains consolidate, and some eventually discontinue ketamine entirely while continuing ERP work.
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This is the most important question for OCD patients and we take it seriously. The 2025 Beaglehole study found that dissociation was particularly distressing for OCD patients whose core fear involves loss of mental control. Dr. Mahjoubi starts OCD patients at lower doses than the general population, screens carefully for this concern during your consult, and adjusts based on your tolerance. If dissociation is intolerable, the program isn't right for you — and we'd rather know that during your consult than after you start.
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This is a contraindication to consider carefully. Some patients with this presentation tolerate ketamine fine at low doses; others find even mild dissociation catastrophic. Dr. Mahjoubi will discuss your specific OCD picture during the consult and may recommend you not pursue ketamine if your tolerance is too low. We won't push it.
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The strongest evidence is for ketamine + ERP. Ketamine alone produces a short-lived effect. Without ERP, you'll likely cycle through ketamine doses without building durable change. Dr. Mahjoubi will discuss your ERP situation during the consult — and may decline to start ketamine if you're not committed to engaging with the behavioral side.
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The International OCD Foundation's provider directory is the best starting point — filter for ERP-trained providers in your state or for telehealth. NOCD also offers ERP-only telehealth therapy that accepts many insurance plans. Make sure any therapist you see specifically practices ERP for OCD — general CBT or talk therapy alone is not the same.
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Treatment-resistant OCD (failure to respond to two or more SSRIs at maximum tolerated doses for 12+ weeks each) is exactly the population the OCD ketamine literature focuses on. You're not unusual — about a third of OCD patients are treatment-resistant. Ketamine + ERP is one of the most evidence-supported next steps.
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The published trials have included contamination, harm, "just right" / symmetry, religious, sexual orientation, relationship, and pure obsessional ("Pure O") subtypes. Effect sizes have been similar across subtypes in the studies to date — but the literature is still small. Dr. Mahjoubi will discuss what's known specific to your subtype during the consult.
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Transcranial magnetic stimulation (deep TMS) is FDA-approved for OCD and is a strong option, especially if you don't tolerate or don't want ketamine. TMS requires daily clinic visits for ~6 weeks. Ketamine is faster onset but requires ERP to sustain. The two can also be combined in some cases. Dr. Mahjoubi will discuss the trade-offs during your consult.
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At prescribed therapeutic doses, ketamine has a low addiction risk and does not produce physical withdrawal. NutraBrain's dosing is designed to avoid tolerance and dependence. Patients with a history of ketamine misuse will be screened during the consult.
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NutraBrain is cash-pay. We provide a superbill you can submit for possible out-of-network reimbursement. Most patients find the $69/mo membership + ketamine cost is less than what they were spending on psychiatry + medications that weren't working.
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If you're in immediate mental health crisis or having thoughts of self-harm, call or text 988 (Suicide & Crisis Lifeline). Ketamine therapy is a longer-term treatment — not a rescue medication. Dr. Mahjoubi can discuss appropriate options during your consult.
You don't have to keep losing hours to your OCD.
The research is real: ketamine + ERP is among the few approaches with rapid effects in treatment-resistant OCD. Only 48 new patient spots are accepted per month nationwide.
No contracts. First month covered. Prescription delivered to your door in every state NutraBrain serves.
Important Medical Disclosure: Ketamine is FDA-approved as an anesthetic and (as esketamine / Spravato) for treatment-resistant depression. Its use for obsessive-compulsive disorder is considered off-label and is supported by the peer-reviewed research cited on this page. Acute effects from a single dose are typically short-lived (~1 week) unless combined with Exposure and Response Prevention (ERP) therapy. Dr. David Mahjoubi, MD’s recommendation for OCD patients is to be evaluated by a psychiatrist, to engage with an ERP-trained therapist during ketamine therapy, and to start at lower ketamine doses than would be used for depression. Individual results vary. This page is informational and does not constitute medical advice.
