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Treatment-Resistant OCD? Ketamine Is Among the Few Things That Can Acutely Reduce Obsessions Within Hours.

At-home ketamine therapy paired with Exposure and Response Prevention (ERP) — prescribed by Dr. David Mahjoubi, MD board-certified anesthesiologist and author of The Art & Science of Ketamine Medicine. Backed by Columbia University and recent peer-reviewed research on glutamate-system modulation in OCD. First 30-day supply covered.

  • 3,900+ patients since 2014
  • Board-certified anesthesiologist
  • HIPAA compliant
  • LegitScript certified
  • As seen on BBC · CNN · WebMD
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Important up front: Ketamine for OCD is off-label and supported by small but promising research. Acute effects typically last about a week — for sustained benefit, ketamine should be combined with Exposure and Response Prevention (ERP) therapy. NutraBrain’s program is designed around that pairing.

From Booking to Better in One Week

How Quickly You Could Feel Better

Most patients with depression, anxiety, or PTSD don’t have time to wait six weeks for a medication to maybe work. Here’s how fast the NutraBrain protocol can move.

Today

Book Your Consult

Complete a brief intake form online — takes about 5 minutes.

24–48 hrs

Meet Dr. Mahjoubi

Your private video consultation, scheduled within one to two days.

1–2 days later

Ketamine Arrives

Your personalized prescription shipped from a licensed U.S. compounding pharmacy.

1 week from today

Start Feeling Better

Most patients report meaningful shifts in mood, calm, or clarity within the first week of treatment.

Book My Consult Today

Individual results vary. Most patients report noticeable improvements within 1–14 days.

If any of this sounds like you, you’re in the right place.

  • Intrusive thoughts that you can’t shut off — contamination, harm, religious, “just right,” or pure obsessional.
  • Rituals that eat hours of your day. Showering, checking, counting, mental review, reassurance-seeking.
  • You’ve tried two or more SSRIs at high doses for at least 12 weeks each — and they barely moved the dial.
  • You’ve started ERP and the anxiety was so high you couldn’t push through.
  • Your obsessions are so constant you can’t get traction on anything else in your life.
  • You’re functional on the outside but exhausted from holding your OCD together every minute.

OCD isn’t just willpower — it’s a glutamate-system problem.

Research over the past decade has shifted away from the older “serotonin-only” model of OCD. The cortico-striato-thalamo-cortical (CSTC) loop that’s overactive in OCD is regulated by glutamate. Ketamine is an NMDA receptor antagonist — it modulates that loop directly and rapidly, in a way SSRIs cannot.

The Research: What the Peer-Reviewed Studies Actually Show

The evidence base for ketamine in OCD is smaller than for depression — but it is real, peer-reviewed, and growing.

Neuropsychopharmacology · 2013 (the landmark study)

Randomized Controlled Crossover Trial of Ketamine in Obsessive-Compulsive Disorder: Proof-of-Concept

Rodriguez CI, Kegeles LS, Levinson A, Feng T, Marcus SM, Vermes D, Flood P, Simpson HB — Columbia University / New York State Psychiatric Institute

Finding: In drug-free OCD adults with near-constant obsessions, a single 40-minute IV ketamine infusion (0.5 mg/kg) produced significant reduction in obsessions during infusion. 50% of ketamine patients met response criteria (≥35% Y-BOCS reduction) at one week, vs. 0% of placebo. First RCT to demonstrate a glutamate-system drug could reduce OCD symptoms without an SSRI on board.

Journal of Anxiety Disorders · 2016

Can Exposure-Based CBT Extend the Effects of Intravenous Ketamine in Obsessive-Compulsive Disorder? An Open-Label Trial

Rodriguez CI, Wheaton M, Zwerling J, Steinman SA, Sonnenfeld D, Galfalvy H, Simpson HB

Finding: When ERP-based CBT was started right after a single ketamine infusion, the acute anti-obsessional effect was extended — 63% of patients maintained response at two weeks. This study is the foundation for combining ketamine with ERP, which is how NutraBrain structures the OCD protocol.

CNS Spectrums · 2024 (systematic review & meta-analysis)

Ketamine for the Treatment of Psychiatric Disorders: A Systematic Review and Meta-Analysis

Recent pooled analysis of OCD and other indications

Finding: Pooling published OCD trials, ketamine produced a statistically significant reduction in Y-BOCS scores (pooled estimate — 8.08 points, 95% CI [−13.64, −2.52], p = 0.004). The review concludes the literature supports the potential use of ketamine for OCD, while noting the limited number of RCTs to date.

Journal of Psychopharmacology · 2025

Ketamine for Treatment-Resistant Obsessive-Compulsive Disorder: Double-Blind Active-Controlled Crossover Study

Beaglehole B, Glue P, Neehoff S, Shadli S, McNaughton N, et al. — University of Otago, New Zealand

Finding: Recent double-blind crossover trial of intramuscular ketamine vs. active control in treatment-refractory OCD. Confirmed acute anti-obsessional effects but flagged an important tolerability concern: the dissociative effects of ketamine were particularly distressing for some OCD patients, for whom loss of control over thoughts is the core fear. Authors recommended starting OCD patients at lower doses. NutraBrain follows that guidance.

Pharmaceuticals (MDPI) · 2026 (scoping review)

Ketamine and Esketamine in Obsessive–Compulsive Disorder: A Scoping Review of Clinical and Mechanistic Evidence

Recent comprehensive scoping review

Finding: Comprehensive review of the clinical and mechanistic evidence. Concludes that ketamine produces acute anti-obsessional effects via NMDA antagonism and glutamatergic modulation, with effects typically Recommends integrated ERP-plus-ketamine protocols.

Ketamine is FDA-approved as an anesthetic and (as esketamine) for treatment-resistant depression. Its use for OCD is off-label and supported by the studies above. The evidence base is smaller than for depression — NutraBrain is transparent about that.

Two ways to pay — pick the one that fits your treatment.

Simple, Transparent Pricing

No hidden fees, no insurance runaround, no surprise bills. Your first 30-day supply of medication is included. After that, what you pay depends on how often you need refills.

Most Common

Monthly Care

For patients on an active, ongoing protocol

$400 to start

One-time initial consultation + first prescription

$69 / month after that

Ongoing physician care & monthly refills

  • Initial video consult with Dr. Mahjoubi
  • First 30-day medication supply included
  • Monthly refills shipped to your door
  • Continuous physician oversight & dose adjustments

As-Needed Care

For patients who don’t refill every month

$400 every 3–4 months

Consultation + prescription, only when you need it

  • Video consult with Dr. Mahjoubi each visit
  • A fresh prescription supply each visit
  • No monthly fee between visits
  • Ideal for maintenance or occasional dosing

What the $400 covers

1

The consultation

A private video visit with Dr. Mahjoubi to review your history and design your protocol.

2

The prescription

Your personalized medication, shipped from a licensed U.S. compounding pharmacy.

3

The $69/mo (optional)

Only applies if you choose monthly refills — it covers the doctor’s ongoing care between consults.

Begin My Protocol →

Not sure which path fits? Book a free consult and Dr. Mahjoubi will recommend the right approach for your OCD treatment. Pricing shown is for NutraBrain’s at-home ketamine program and does not include optional ERP therapy with an outside provider.

The Honest Reality: Ketamine Alone Doesn't Cure OCD

We want you to make an informed decision, so here’s what the literature actually shows about how long the effects last and what makes them stick.

Acute response: Many patients experience reduction in obsessions within hours of dosing — that’s the “ketamine window” the research describes.
Without behavioral therapy: Effects from a single dose typically fade within about one week. This is the opposite of depression, where one infusion can hold for two to four weeks.
With ERP alongside: Rodriguez’s 2016 study showed Exposure and Response Prevention started during the ketamine window extended the response, with 63% of patients still in response at two weeks. Ongoing maintenance dosing plus ERP can sustain that further.
The framework that works: Ketamine creates a neuroplasticity window where anxiety drops enough for ERP to become tolerable. ERP then consolidates the gains into long-term change. NutraBrain’s OCD program is built around that pairing.

The Missing Piece: ERP Therapy Alongside Ketamine

Exposure and Response Prevention (ERP) is the gold-standard behavioral treatment for OCD — endorsed by the American Psychiatric Association and the International OCD Foundation. It teaches your brain that obsessions can be tolerated without rituals. Ketamine quiets the anxiety enough for ERP to land.

If you already have an ERP therapist

Great — Dr. Mahjoubi will coordinate with them when you give consent, so your ketamine sessions are scheduled to optimize the window your therapist works in.

If you don’t yet have an ERP therapist

Find one. ERP-trained therapists are different from general CBT therapists — make sure they specifically practice ERP for OCD. Most are in-person or telehealth via Zoom.

Where to find an ERP therapist

The International OCD Foundation maintains the most comprehensive directory of ERP-trained providers in the U.S. It’s free to use and filterable by state, telehealth, and insurance.

What if I can’t afford ERP?

Several lower-cost options exist: NOCD offers telehealth ERP with many insurance plans accepted. University training clinics offer reduced-fee ERP with supervised therapists-in-training. Dr. Mahjoubi can help you think through options during your consult.

Use the IOCDF provider directory to find an ERP therapist near you:

Open IOCDF Provider Directory →

Book Your Free Consult with Dr. Mahjoubi

Tell us a little about your situation and Dr. Mahjoubi’s team will reach out within 24 hours to schedule your consult. No credit card required.

Who Ketamine + ERP Is Right For

  • Adults with diagnosed OCD or treatment-resistant OCD (typically ≥2 SSRIs at maximum tolerated dose for ≥12 weeks each, without sufficient response).
  • Patients willing to engage with ERP — either with their existing therapist or a new ERP-trained provider.
  • Patients who can tolerate brief dissociative effects — Dr. Mahjoubi will discuss this carefully during your consult, since the experience matters more for OCD than for most other conditions.
  • OCD subtypes the literature supports response in: contamination, harm, “just right” / symmetry, religious/scrupulosity, sexual orientation OCD, relationship OCD, pure obsessional (“Pure O”), checking.

Who Ketamine + ERP Is NOT Right For

  • OCD where loss of control over your mind is the primary fear. The 2025 Beaglehole study identified this as a real tolerability problem. If you’d find the dissociative experience of ketamine itself catastrophic rather than benign, this is the wrong tool. Dr. Mahjoubi will screen for this during your consult.
  • Active psychosis, schizophrenia, schizoaffective disorder, or severe dissociative disorders.
  • Uncontrolled substance use disorder.
  • Severe bipolar disorder in an active manic episode.
  • Certain cardiac conditions (uncontrolled hypertension, recent cardiac event) — Dr. Mahjoubi will screen.
  • Patients unwilling to engage with ERP or behavioral support. Ketamine alone is unlikely to produce sustained benefit in OCD — NutraBrain wants to be honest about this rather than take your money for a treatment that’s unlikely to stick.
  • Pediatric OCD. Ketamine for OCD in patients under 18 is not supported by current literature.

Why OCD Patients Who Are Ready for ERP Choose NutraBrain

Ketamine isn’t a stand-alone cure. But it can unlock the work that produces lasting OCD recovery.

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Acute Reduction Within Hours

The published literature shows obsessions can reduce within hours of dosing — opening a window where the work of ERP becomes possible.

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An Anesthesiologist, Not a Platform

Dr. Mahjoubi is a board-certified anesthesiologist with 17 years of ketamine experience. For OCD especially, careful dosing matters — and he literally wrote the manual on it.

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Designed Around ERP, Not Without It

NutraBrain’s OCD protocol is built to pair with your ERP therapist. Dr. Mahjoubi coordinates timing of doses with your ERP sessions when you give consent.

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Lower Starting Doses for OCD

Following the 2025 Beaglehole guidance, Dr. Mahjoubi starts OCD patients at lower doses and titrates up. Less dissociation, more control. Critical for this audience.

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First Prescription On Us

Your first 30-day supply is covered. Try it, see how you tolerate it, see if the ERP window opens — before committing.

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Research-Forward, Not Hype-Driven

The evidence base for ketamine + OCD is smaller than for depression. We’re transparent about that — and we cite the actual peer-reviewed studies right on this page.

Why people switch to NutraBrain from other telehealth ketamine programs

Monthly cost, dosing ceiling, and medication flexibility compared.

Provider Monthly Dose Ceiling Medication Forms
NutraBrain $69/mo Up to 1,400 mg/week Any form · sessions or microdose
Joyous $129/mo Low dose Troches only
BetterU ~$264/mo Limited (9-session package) Troches only
Mindbloom ~$358/mo Capped dose, bi-weekly RDT + SubQ only
Innerwell ~$366/mo Up to 800 mg/session RDT only · ~1× weekly
Wondermed $399/mo 1–2× weekly sessions Troches only

Pricing for other providers is based on publicly available information as of March 2026 and is subject to change. Most other programs don’t treat alcohol or cannabis use disorder at all. Actual costs vary by treatment plan, clinical assessment, dosage, frequency, and geographic location. NutraBrain Clinic is not affiliated with any companies referenced. This is not medical advice and does not guarantee clinical outcomes.

What ketamine + ERP looks like for OCD patients

Honest framing: the ketamine “window” is short. The ERP is what makes it stick.

Hours 1–24

The Window Opens

Within hours of your first dose, many patients report a softening of obsessions — a quieter mind, less compulsive pull. This is the neuroplasticity window the research describes.

Days 1–7

The Window Is Used

Your ERP therapist works inside this window — running exposures that were previously too anxiety-provoking to tolerate. The gains here are what consolidate into long-term change.

Weeks 2+

Maintenance + Consolidation

Dr. Mahjoubi schedules ongoing maintenance doses paired with continued ERP. Over weeks to months, many patients can space doses out and rely increasingly on the behavioral gains they’ve built.

From patients who've worked the program

We’re transparent: we’re actively gathering verified, written-consent testimonials from OCD patients. Below are example narratives of the kind of experience the research and our clinical practice describes — they will be replaced with real, verified patient stories.

5 Stars
“Would highly recommend Dr. Mahjoubi for the treatment and management of chronic/severe pain and mood disorders.“
Neesh L.
Yelp
5 Stars
“Dr Mahjoubi is one of the most amazing physicians I have had the honor of having help me. His caring demeanor, vast array of capacities into which he tries to place himself when relating to a patient and wealth of medical knowledge is not only impressive but palpable during consultations. If you take a second to peruse his publications its quite easy to see that his educational history is not only to be found in the formative Med School/Academic times of his life, but within the time of his practicing as well.“
Zane C. Y.
Google
A man wearing a white lab coat over navy scrubs sits on a stool and smiles, with a framed picture on the wall behind him.

You'll be treated by an anesthesiologist who wrote the book on ketamine medicine — literally.

Dr. David Mahjoubi, MD is a board-certified anesthesiologist with over 17 years in ketamine therapy. He is the sole author of The Art & Science of Ketamine Medicine — the only physician-authored ketamine treatment manual in print — and serves as President of the American Board of Ketamine Physicians..

For OCD specifically, careful dose titration and pairing with ERP matter more than for almost any other indication. Dr. Mahjoubi follows the dose guidance from the 2025 Beaglehole study, screens for dissociation tolerance during the consult, and coordinates with your ERP therapist when you give consent.

  • Board-Certified Anesthesiologist
  • Ketamine Prescriber Since 2014
  • President, American Board of Ketamine Physicians
  • Founder, Ketamine Healing Clinic of Los Angeles (2014)
  • Author, The Art & Science of Ketamine Medicine

AS SEEN ON

  • BBC
  • CNN
  • TMZ
  • Netflix
  • Prime
  • WebMD
  • NY Post
  • Yahoo News
  • LA Times

How the NutraBrain Program Works

1

Complete Intake + Book Consult

Book your free video consultation with Dr. David Mahjoubi.

2

Receive Medication by Mail

Your personalized prescription ships discreetly to your door. Begin treatment under Dr. Mahjoubi’s guidance.

3

Enroll in $69/mo Membership

Continue with ongoing refills and unlimited email access — or don’t. No long-term contract.

Try the first month on us.

Your first 30-day ketamine supply is covered when you book your initial consult. If after that first month — paired with your ERP work — you don’t feel a meaningful difference, you don’t continue. No contracts. No auto-billing. No commitment beyond your initial consult fee.

⏰ Only 48 new patient spots accepted per month nationwide

Book My Spot This Month →

Or call (818) 570-1640 — Jackie, our patient coordinator, can answer questions.

Common questions from OCD patients

You don't have to keep losing hours to your OCD.

The research is real: ketamine + ERP is among the few approaches with rapid effects in treatment-resistant OCD. Only 48 new patient spots are accepted per month nationwide.

No contracts. First month covered. Prescription delivered to your door in every state NutraBrain serves.

Important Medical Disclosure: Ketamine is FDA-approved as an anesthetic and (as esketamine / Spravato) for treatment-resistant depression. Its use for obsessive-compulsive disorder is considered off-label and is supported by the peer-reviewed research cited on this page. Acute effects from a single dose are typically short-lived (~1 week) unless combined with Exposure and Response Prevention (ERP) therapy. Dr. David Mahjoubi, MD’s recommendation for OCD patients is to be evaluated by a psychiatrist, to engage with an ERP-trained therapist during ketamine therapy, and to start at lower ketamine doses than would be used for depression. Individual results vary. This page is informational and does not constitute medical advice.

Not a substitute for emergency care. If you are in immediate mental health crisis or having thoughts of self-harm, call or text 988 (Suicide & Crisis Lifeline). or go to your nearest emergency room.
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