I've tried 3 antidepressants and nothing worked. Will ketamine work for me?

Treatment-resistant depression (TRD) is one of the conditions ketamine is best studied for. The FDA has approved a ketamine derivative (esketamine, Spravato) specifically for TRD. Studies on generic ketamine show 50–70% response rates in patients who haven't responded to two or more antidepressants. Dr. Mahjoubi has been prescribing for TRD patients since 2014.

Do I need to stop my current antidepressant?

No. Ketamine is typically added alongside your current regimen. As you respond, your psychiatrist may help you taper. Dr. Mahjoubi coordinates with your existing psychiatrist when you give consent.

How fast will I feel a difference?

Most NutraBrain depression patients report a meaningful shift within 1–14 days. Some feel it during their first dose. Compare that to SSRIs, which typically take 4–6 weeks.

Is this safe at home?

Yes, when prescribed by a physician and used at therapeutic doses. NutraBrain's nasal spray, troche, and RDT formulations are all at sub-anesthetic doses. You'll be screened for contraindications (active psychosis, uncontrolled substance use disorder, certain cardiac conditions) during your consult.

What about side effects?

Mild dizziness, nausea, or short dissociation during dosing are the most common. These resolve quickly. Severe side effects are rare at the doses NutraBrain prescribes.

Is ketamine addictive?

At prescribed therapeutic doses, the addiction risk is low. Unlike opioids or benzos, ketamine doesn't produce physical withdrawal. NutraBrain's dosing protocol is specifically designed to avoid tolerance and dependence.

Will insurance cover this?

NutraBrain is cash-pay. Most patients find the $69/mo membership + ketamine cost is significantly less than their psychiatry + SSRI out-of-pocket. We provide a superbill you can submit to your insurance for possible out-of-network reimbursement.

What if I'm having thoughts of suicide?

If you're in immediate crisis, call or text 988 (Suicide & Crisis Lifeline). Ketamine has been studied specifically for acute suicidal ideation in clinical settings — but at-home telehealth is not the right setting for an active crisis. Dr. Mahjoubi can discuss this with you during your consult.

Depression That Hasn't Responded to Antidepressants? You Have Another Option.

At-home ketamine therapy, prescribed and managed by Dr. David Mahjoubi — board-certified physician, President of the American Board of Ketamine Physicians, prescribing ketamine since 2014. Most patients report meaningful relief within 1–14 days. First 30-day supply covered.

Book My Free Consult with Dr. Mahjoubi →Begin Protocol →Take the 60-second quiz: Is ketamine right for me? →

3,900+ patients since 2014
5★ on Google & Yelp
HIPAA compliant
LegitScript certified
As seen on BBC · CNN · WebMD

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From Booking to Better in One Week

How Quickly You Could Feel Better

Most patients with depression, anxiety, or PTSD don’t have time to wait six weeks for a medication to maybe work. Here’s how fast the NutraBrain protocol can move.

Today

Book Your Consult

Complete a brief intake form online — takes about 5 minutes.

24–48 hrs

Meet Dr. Mahjoubi

Your private video consultation, scheduled within one to two days.

1–2 days later

Ketamine Arrives

Your personalized prescription shipped from a licensed U.S. compounding pharmacy.

1 week from today

Start Feeling Better

Most patients report meaningful shifts in mood, calm, or clarity within the first week of treatment.

Book My Consult Today

Individual results vary. Most patients report noticeable improvements within 1–14 days.

If any of this sounds like you, you’re in the right place.

You’ve tried two or more antidepressants and they didn’t work — or worked, then stopped.
You spend most days feeling numb, foggy, or just going through the motions.
You’ve been told “you just need to give it more time” — for months.
You’re functional on the outside but exhausted on the inside.
You’re afraid your depression is becoming a permanent part of who you are.

Ketamine works differently than every antidepressant you’ve tried.

It doesn’t take six weeks. It doesn’t slowly adjust your serotonin. It rebuilds neural connections — and most patients feel it within days.

Book My Free Consult →Begin Protocol →

Six Reasons Depression Patients Choose NutraBrain

Most at-home ketamine programs are built for scale. NutraBrain is built for outcomes.

Outline of a calendar with a heart and a heartbeat line in front, symbolizing scheduling or tracking health-related events or appointments.

Relief in Days, Not Months

SSRIs take 4–6 weeks. Most NutraBrain patients report meaningful shifts within 1–14 days. Your life doesn’t have time to wait.

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A Pioneer, Not a Platform

Treated personally by Dr. Mahjoubi — one of the first doctors in America to prescribe at-home ketamine. Not a rotating clinician. Not a chatbot.

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The Only Oxytocin + Ketamine Formula in America

Our exclusive nasal spray combines ketamine with oxytocin for emotional connection and breaking through emotional numbness. Available nowhere else.

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Built Around Your Brain, Not a Template

Five delivery formats. Sessions or daily microdosing. Up to 1,400mg per week — the highest ceiling in telehealth. Your protocol, not a subscription box.

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First Prescription On Us

Your first 30-day supply is covered. Try the protocol, meet Dr. Mahjoubi, experience the difference — before committing.

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Simple, Respectful Refills

Once Dr. Mahjoubi knows you, you don’t re-consult every month. 1–2 video visits per year, unlimited email access in between.

Book Your Free Consult with Dr. Mahjoubi

Tell us a little about your situation and Dr. Mahjoubi’s team will reach out within 24 hours to schedule your consult. No credit card required.

Why people switch to NutraBrain from other telehealth ketamine programs

Monthly cost, dosing ceiling, and medication flexibility compared.

Provider	Monthly	Dose Ceiling	Medication Forms
NutraBrain	$69/mo	Up to 1,400 mg/week	Any form · sessions or microdose
Joyous	$129/mo	Low dose	Troches only
BetterU	~$264/mo	Limited (9-session package)	Troches only
Mindbloom	~$358/mo	Capped dose, bi-weekly	RDT + SubQ only
Innerwell	~$366/mo	Up to 800 mg/session	RDT only · ~1× weekly
Wondermed	$399/mo	1–2× weekly sessions	Troches only

Pricing for other providers is based on publicly available information as of March 2026 and is subject to change. Most other programs don’t treat alcohol or cannabis use disorder at all. Actual costs vary by treatment plan, clinical assessment, dosage, frequency, and geographic location. NutraBrain Clinic is not affiliated with any companies referenced. This is not medical advice and does not guarantee clinical outcomes.

Claim My Covered First Month →

Two Ways to Begin with NutraBrain

Choose Your Path

Whether you’re working through a specific issue or seeking ongoing care, choose the plan that fits where you are.

Pay as you go

Short-Term Reset

A focused, time-limited course of ketamine therapy. No subscription required.

$400/ visit

One flat fee. No recurring charges.

What’s Included

Video consultation with Dr. Mahjoubi
One personalized 30 to 60 day prescription paid for by NutraBrain
No subscription, no auto-renewal
Need more medication later? Book another $400 visit anytime — includes a fresh consult.

Best For

First-time patients, working through a specific issue, or occasional refills a few times per year.

Start a Short-Term Reset

Best Value for Ongoing Care

Long-Term Care

An ongoing relationship with Dr. Mahjoubi, with email access and effortless refills.

$400 + $69/mo

Or pay $950/year upfront — save $278 vs monthly billing.

What’s Included

Initial video consultation with Dr. Mahjoubi
First 30-day prescription included
$69 per month subscription available after first video consultation
Unlimited email access to Dr. Mahjoubi
Effortless refills every 3–4 months — no new visit required
1–2 brief video check-ins per year
Cancel anytime

Best For

Chronic depression, anxiety, PTSD, or chronic pain — where consistent physician oversight matters most.

Start Long-Term Care

Only 48 patient spots awarded per month nationwide.

What ketamine therapy looks like for depression patients

Most NutraBrain depression patients move through a similar arc.

Days 1–3

The Fog Starts to Lift

Most patients report a lift — described as the fog clearing, or “feeling like myself again.” Some feel something during their very first dose.

Weeks 2–4

Sustained Improvement

Mood, motivation, and the ability to engage with daily life all improve. Many patients begin tapering off SSRIs under their psychiatrist’s supervision.

Months 2–6

Maintenance, Then Often Off

Most patients move to a maintenance schedule — fewer doses, longer intervals. Some discontinue treatment entirely.

Start My Journey →Begin Protocol →

From depression patients who've made the switch

5 Stars

“I was suffering from PTSD and depression and considering sucide, this treatment saved my life “
Michael H.
Google

5 Stars

“Very ethical and knowledgeable doctor. Highly recommend ketamine treatment for severe depression or anxiety“
Jen Y.
Google

5 Stars

“Dr. Mahjoubi is a very accessible and caring doctor and the ketamine treatments are invaluable for a sufferer of major depression. thank you dr.“
Michael I.
Google

A man wearing a white lab coat over navy scrubs sits on a stool and smiles, with a framed picture on the wall behind him.

You'll be treated by the doctor who wrote the book on ketamine medicine — literally.

Dr. David Mahjoubi, MD is a board-certified anesthesiologist with over 17 years in ketamine therapy, the sole author of The Art & Science of Ketamine Medicine — the only physician-authored ketamine treatment manual in print — and serves as President of the American Board of Ketamine Physicians.

He has been interviewed about ketamine therapy by the BBC, CNN, TMZ, WebMD, the Los Angeles Times, the New York Post, and others. He personally evaluates and prescribes for every NutraBrain patient.

Board-Certified Anesthesiologist
Ketamine Prescriber Since 2014
President, American Board of Ketamine Physicians
Founder, Ketamine Healing Clinic of Los Angeles (2014)
Author, The Art & Science of Ketamine Medicine

AS SEEN ON

BBC
CNN
TMZ
Netflix
Prime
WebMD
NY Post
Yahoo News
LA Times

How the NutraBrain Program Works

1

Complete Intake + Book Consult

Book your free video consultation with Dr. David Mahjoubi.

2

Receive Medication by Mail

Your personalized prescription ships discreetly to your door. Begin treatment under Dr. Mahjoubi’s guidance.

3

Enroll in $69/mo Membership

Continue with ongoing refills and unlimited email access — or don’t. No long-term contract.

Get My Personalized Protocol →

Try the first month on us.

Your first 30-day ketamine supply is covered when you book your initial consult. If after that first month you don’t feel a meaningful difference, you don’t continue. No contracts. No auto-billing. No commitment beyond your initial consult fee.

⏰ Only 48 new patient spots accepted per month nationwide

Book My Spot This Month →

Or call (818) 570-1640 — Jackie, our patient coordinator, can answer questions.

Common questions from depression patients

: Treatment-resistant depression (TRD) is one of the conditions ketamine is best studied for. The FDA has approved a ketamine derivative (esketamine, Spravato) specifically for TRD. Studies on generic ketamine show 50–70% response rates in patients who haven't responded to two or more antidepressants. Dr. Mahjoubi has been prescribing for TRD patients since 2014.
: No. Ketamine is typically added alongside your current regimen. As you respond, your psychiatrist may help you taper. Dr. Mahjoubi coordinates with your existing psychiatrist when you give consent.
: Most NutraBrain depression patients report a meaningful shift within 1–14 days. Some feel it during their first dose. Compare that to SSRIs, which typically take 4–6 weeks.
: Yes, when prescribed by a physician and used at therapeutic doses. NutraBrain's nasal spray, troche, and RDT formulations are all at sub-anesthetic doses. You'll be screened for contraindications (active psychosis, uncontrolled substance use disorder, certain cardiac conditions) during your consult.
: Mild dizziness, nausea, or short dissociation during dosing are the most common. These resolve quickly. Severe side effects are rare at the doses NutraBrain prescribes.
: At prescribed therapeutic doses, the addiction risk is low. Unlike opioids or benzos, ketamine doesn't produce physical withdrawal. NutraBrain's dosing protocol is specifically designed to avoid tolerance and dependence.
: NutraBrain is cash-pay. Most patients find the $69/mo membership + ketamine cost is significantly less than their psychiatry + SSRI out-of-pocket. We provide a superbill you can submit to your insurance for possible out-of-network reimbursement.
: If you're in immediate crisis, call or text 988 (Suicide & Crisis Lifeline). Ketamine has been studied specifically for acute suicidal ideation in clinical settings — but at-home telehealth is not the right setting for an active crisis. Dr. Mahjoubi can discuss this with you during your consult.

Don't give your depression another six weeks to "see if it lifts."

Most patients start feeling better within days of their first dose. Only 48 new patient spots are accepted per month nationwide.

Book My Consult This Week →Call (818) 570-1640 Begin Protocol →

No contracts. First month covered. Prescription delivered to your door in every state NutraBrain serves.

Important Medical Disclosure: Dr. David Mahjoubi, MD’s official recommendation is for patients to see a psychiatrist first and for an adequate amount of time to assess response to traditional methods that combat depression, anxiety, and PTSD (and a pain management physician for chronic pain). Dr. Mahjoubi further recommends ongoing involvement of a psychiatrist during ketamine therapy, as he is not a psychiatrist. Individual results vary. This comparison is intended for informational purposes only and does not constitute medical advice.

Not a substitute for emergency care. If you are in immediate crisis or having thoughts of self-harm, call or text 988 (Suicide & Crisis Lifeline) or go to your nearest emergency room.

Depression That Hasn't Responded to Antidepressants? You Have Another Option.

From Booking to Better in One Week

Today

Book Your Consult

24–48 hrs

Meet Dr. Mahjoubi

1–2 days later

Ketamine Arrives

1 week from today

Start Feeling Better

If any of this sounds like you, you’re in the right place.

Ketamine works differently than every antidepressant you’ve tried.

Six Reasons Depression Patients Choose NutraBrain

Relief in Days, Not Months

A Pioneer, Not a Platform

The Only Oxytocin + Ketamine Formula in America

Built Around Your Brain, Not a Template

First Prescription On Us

Simple, Respectful Refills

Book Your Free Consult with Dr. Mahjoubi

Why people switch to NutraBrain from other telehealth ketamine programs

Two Ways to Begin with NutraBrain

Short-Term Reset

What’s Included

Best For

Long-Term Care

What’s Included

Best For

What ketamine therapy looks like for depression patients

Days 1–3

The Fog Starts to Lift

Weeks 2–4

Sustained Improvement

Months 2–6

Maintenance, Then Often Off

From depression patients who've made the switch

You'll be treated by the doctor who wrote the book on ketamine medicine — literally.

AS SEEN ON

How the NutraBrain Program Works

1

Complete Intake + Book Consult

2

Receive Medication by Mail

3

Enroll in $69/mo Membership

Try the first month on us.

Common questions from depression patients

Don't give your depression another six weeks to "see if it lifts."

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