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Ketamine for Alcoholism and Marijuana Addiction

Backed by peer-reviewed research from Columbia University and the American Journal of Psychiatry. At-home ketamine therapy for alcohol use disorder and cannabis use disorder — prescribed by Dr. David Mahjoubi, MD, board-certified anesthesiologist and author of The Art & Science of Ketamine Medicine. First 30-day supply covered.

  • 3,900+ patients since 2014
  • Board-certified anesthesiologist
  • HIPAA compliant
  • LegitScript certified
  • As seen on BBC · CNN · WebMD
The treatment of rhinitis. Girl dripping nose drops
This program treats alcohol use disorder and cannabis use disorder only. We do not treat cocaine, methamphetamine, opioid, benzodiazepine, or polysubstance use disorders at NutraBrain. If that’s what you’re looking for, please see below for the right resources.

If any of this sounds like you, you’re in the right place.

  • You said you’d stop after one drink — and didn’t.
  • You’ve tried Naltrexone, Antabuse, or Campral — and it didn’t stick.
  • You’ve done AA, SMART Recovery, or rehab — and the cravings are still there.
  • You’ve been smoking weed daily for years and you can’t picture life without it.
  • You use cannabis to sleep, to relax, to function — and you’ve lost the off-switch.
  • You know it’s affecting your relationships, your work, your health — and you still can’t stop.
  • You’ve tried “white-knuckling it” and the craving always wins.

Ketamine works on the brain circuits that drive craving — not just willpower.

Alcohol and cannabis both hijack the brain’s reward system (the nucleus accumbens and prefrontal cortex) and rewire it to crave more. Ketamine is an NMDA receptor antagonist. It interrupts the consolidation of craving memories and promotes BDNF — the neuroplasticity protein that lets your brain “unlearn” addictive patterns. Combined with brief therapy, the research shows this can substantially extend abstinence.

The Research: What the Peer-Reviewed Studies Actually Show

Ketamine for alcohol and cannabis use disorder is one of the most actively researched non-FDA-approved uses of ketamine. Here are the most-cited human clinical trials.

American Journal of Psychiatry · Feb 2020

A Single Ketamine Infusion Combined With Motivational Enhancement Therapy for Alcohol Use Disorder

Dakwar E, Levin F, Hart CL, Basaraba C, Choi J, Pavlicova M, Nunes EV — Columbia University / New York State Psychiatric Institute

Finding: A single 52-minute IV ketamine infusion (0.71 mg/kg) combined with motivational enhancement therapy significantly increased the likelihood of abstinence, delayed the time to relapse, and reduced heavy drinking days compared with midazolam control. Effects persisted over 21 days of follow-up.

American Journal of Psychiatry · 2022

Adjunctive Ketamine With Relapse Prevention–Based Psychological Therapy in the Treatment of Alcohol Use Disorder (KARE Trial)

Grabski M, McAndrew A, Lawn W, et al. — University of Exeter / University College London

Finding: In a UK randomized controlled trial of 96 patients with severe alcohol use disorder, three weekly low-dose ketamine infusions combined with manualized psychological therapy produced significantly more days of abstinence over six months than either ketamine alone or placebo + therapy. This was the largest controlled trial of its kind.

Journal of Substance Abuse Treatment · 20

Ketamine-Facilitated Behavioral Treatment for Cannabis Use Disorder

Azhari N, Hu H, O’Malley SS, et al.

Finding: A proof-of-concept trial showed that ketamine combined with motivational enhancement and mindfulness-based relapse prevention reduced weekly cannabis use and increased patient confidence in abstinence. This was among the first human studies of ketamine for cannabis use disorder.

Frontiers in Psychiatry · 2018 (Systematic Review)

Efficacy of Ketamine in the Treatment of Substance Use Disorders: A Systematic Review

Jones JL, Mateus CF, Malcolm RJ, Brady KT, Back SE — Medical University of South Carolina

Finding: Reviewing the published human and animal evidence, the authors concluded that ketamine appears to enhance multiple addiction-relevant outcomes — motivation to quit, abstinence, reduced cravings — across alcohol, cocaine, opioid, and cannabis disorders, particularly when paired with behavioral therapy. (Note: NutraBrain treats alcohol and cannabis only.)

Journal of Substance Use & Addiction Treatment · 2025 (Systematic Review)

Role of Ketamine in the Treatment of Substance Use Disorders

Recent systematic review of 14 studies, 551 participants

Finding: Across all reviewed studies, ketamine demonstrated substantial reduction in cravings and withdrawal symptoms, and improved abstinence rates, especially when paired with therapy. The authors emphasize the need for larger trials to define optimal dosing.

Important: Ketamine is FDA-approved as an anesthetic and (as esketamine) for treatment-resistant depression. Its use for alcohol use disorder and cannabis use disorder is considered off-label and supported by the studies above. Outcomes vary by individual.

Six Reasons People Choose NutraBrain for Alcohol or Cannabis Cravings

Most at-home ketamine programs are built for mental health. NutraBrain protocols are designed by an anesthesiologist who wrote the manual.

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Targets the Craving Circuit

Ketamine acts on the NMDA receptor and modulates the reward circuitry that alcohol and cannabis hijack. It interrupts craving consolidation rather than just dulling the urge.

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An Anesthesiologist, Not a Platform

Dr. Mahjoubi is a board-certified anesthesiologist — the specialty that has been using ketamine for decades. He literally wrote the physician manual on ketamine medicine. Not a rotating clinician. Not a chatbot.

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Works Alongside AA, SMART Recovery, or Therapy

The strongest evidence is for ketamine plus behavioral support. Keep your group, your sponsor, your therapist — ketamine adds a tool, it doesn’t replace your recovery system.

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Built for Your Pattern

Daily microdose, weekly session, or a hybrid — Dr. Mahjoubi tailors the protocol to whether you’re trying to quit completely or moderate, what you’ve already tried, and how heavy your use has been.

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First Prescription On Us

Your first 30-day supply is covered. Try the protocol, meet Dr. Mahjoubi, see if your cravings actually shift — before committing.

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Private. Discreet. From Home.

No clinic waiting room, no employer’s insurance trail, no medical-record fingerprint at a rehab. Just a video visit and a prescription that ships to your door.

Book Your Free Consult with Dr. Mahjoubi

Tell us a little about your situation and Dr. Mahjoubi’s team will reach out within 24 hours to schedule your consult. No credit card required.

Who NutraBrain Does NOT Treat for Addiction

NutraBrain’s at-home ketamine program is appropriate only for alcohol use disorder and cannabis use disorder. It is not a substitute for medical detox, residential treatment, or specialized addiction medicine for the following situations:

  • Cocaine, methamphetamine, or other stimulant use disorder — please contact a specialist or SAMHSA (see below).
  • Opioid use disorder — medication-assisted treatment with buprenorphine, methadone, or naltrexone is the evidence-based standard. Please see an addiction-medicine specialist.
  • Benzodiazepine dependence — withdrawal is medically dangerous and requires supervised taper.
  • Polysubstance use disorder — requires in-person, supervised care.
  • Active alcohol withdrawal (tremor, sweating, nausea, hallucinations, or a history of seizures during withdrawal) — alcohol withdrawal can be fatal and requires medical detox first.
  • Heavy daily drinking that has not yet been medically evaluated — Dr. Mahjoubi may require medical detox clearance from your PCP before starting ketamine.

If your situation fits any of the above, please reach out to SAMHSA’s National Helpline at 1-800-662-HELP (4357) — free, confidential, 24/7.

Why people switch to NutraBrain from other telehealth ketamine programs

Monthly cost, dosing ceiling, and medication flexibility compared.

Provider Monthly Dose Ceiling Medication Forms
NutraBrain $69/mo Up to 1,400 mg/week Any form · sessions or microdose
Joyous $129/mo Low dose Troches only
BetterU ~$264/mo Limited (9-session package) Troches only
Mindbloom ~$358/mo Capped dose, bi-weekly RDT + SubQ only
Innerwell ~$366/mo Up to 800 mg/session RDT only · ~1× weekly
Wondermed $399/mo 1–2× weekly sessions Troches only

Pricing for other providers is based on publicly available information as of March 2026 and is subject to change. Most other programs don’t treat alcohol or cannabis use disorder at all. Actual costs vary by treatment plan, clinical assessment, dosage, frequency, and geographic location. NutraBrain Clinic is not affiliated with any companies referenced. This is not medical advice and does not guarantee clinical outcomes.

What ketamine therapy looks like for alcohol or cannabis cravings

Response varies by individual. Here’s the typical arc.

Days 1–14

Cravings Soften

Many patients report a noticeable drop in craving intensity within the first one to two weeks. Sleep often improves first — which removes one common trigger for use.

Weeks 2–6

Behavior Starts to Shift

The “automatic” pull toward the bottle or the joint weakens. Patients report it becomes easier to pause, to choose differently, to engage with their recovery support without white-knuckling it.

Months 2–6

New Patterns Stick

With therapy or recovery work alongside ketamine, many patients report sustained abstinence or significant moderation. Maintenance dosing is individualized.

From patients who've worked the program

5 Stars
“Hello I’m just checking in to say this medicine seems to be a miracle to me. I can’t say enough, it really makes getting sober from alcohol, not only easier, but it makes it possible to walk into the same bars and restaurants I used to drink in without any craving for alcohol. I totally believe this medicine in conjunction with Ibogaine can very well be the cure for addiction one day. I have not used Ibogaine in over a decade, but this medicine reminds me of the very deep benefits I experienced with the Ibogaine. It is truly amazing, 40+ years of drinking with very little success with sobriety, it seems all behind me.“
George F.
Yelp
5 Stars
“Wow, it’s been several years now and I can’t believe I never left a review (then again I had no idea they were on Yelp). Both Dr. Mahjoubi and his staff was incredibly responsive when I had any questions or concerns. I was on the program for about 6 months or so and it helped me at a time nothing else would. I went off it after to try TMS which was a total waste of time and money. My situation changed financially so I couldn’t afford to go back but I honestly felt like it was very helpful while I was in the program. Compared to other Ketamine options, I found his pricing to be reasonable for the care offered and would not hesitate to return should my finances allow.“
Wayne B.
Yelp
5 Stars
“Dr Mahjoubi is one of the most amazing physicians I have had the honor of having help me. His caring demeanor, vast array of capacities into which he tries to place himself when relating to a patient and wealth of medical knowledge is not only impressive but palpable during consultations. If you take a second to peruse his publications its quite easy to see that his educational history is not only to be found in the formative Med School/Academic times of his life, but within the time of his practicing as well.“
Zane C. Y.
Google
A man wearing a white lab coat over navy scrubs sits on a stool and smiles, with a framed picture on the wall behind him.

You'll be treated by an anesthesiologist who wrote the book on ketamine medicine — literally.

Dr. David Mahjoubi, MD is a board-certified anesthesiologist with over 17 years in ketamine therapy. He is the sole author of The Art & Science of Ketamine Medicine — the only physician-authored ketamine treatment manual in print — and serves as President of the American Board of Ketamine Physicians.

Addiction medicine sits at the intersection of pharmacology, behavioral health, and recovery support. Dr. Mahjoubi’s anesthesiology background gives him the pharmacological depth; his framework respects the role of therapy and recovery programs in long-term outcomes. He personally evaluates and prescribes for every NutraBrain patient.

  • Board-Certified Anesthesiologist
  • Ketamine Prescriber Since 2014
  • President, American Board of Ketamine Physicians
  • Founder, Ketamine Healing Clinic of Los Angeles (2014)
  • Author, The Art & Science of Ketamine Medicine

AS SEEN ON

  • BBC
  • CNN
  • TMZ
  • Netflix
  • Prime
  • WebMD
  • NY Post
  • Yahoo News
  • LA Times

How the NutraBrain Program Works

1

Complete Intake + Book Consult

Book your free video consultation with Dr. David Mahjoubi.

2

Receive Medication by Mail

Your personalized prescription ships discreetly to your door. Begin treatment under Dr. Mahjoubi’s guidance.

3

Enroll in $69/mo Membership

Continue with ongoing refills and unlimited email access — or don’t. No long-term contract.

Try the first month on us.

Your first 30-day ketamine supply is covered when you book your initial consult. If after that first month your cravings haven’t budged, you don’t continue. No contracts. No auto-billing. No commitment beyond your initial consult fee.

⏰ Only 48 new patient spots accepted per month nationwide

Book My Spot This Month →

Or call (818) 570-1640 — Jackie, our patient coordinator, can answer questions.

Common questions about ketamine for alcohol or cannabis use

The craving doesn't have to win every time.

The research shows ketamine + therapy substantially extends abstinence. Only 48 new patient spots are accepted per month nationwide.

No contracts. First month covered. Prescription delivered to your door in every state NutraBrain serves.

Important Medical Disclosure: Ketamine is FDA-approved as an anesthetic and (as esketamine / Spravato) for treatment-resistant depression. Its use for alcohol use disorder and cannabis use disorder is considered off-label and is supported by the peer-reviewed research cited on this page. Dr. David Mahjoubi, MD’s recommendation is for patients to be evaluated by a primary care physician (and, when relevant, an addiction medicine specialist) prior to and during ketamine therapy. Alcohol withdrawal can be medically dangerous; do not attempt rapid cessation of heavy daily alcohol use without medical supervision. Tapering of any prescribed medication should be done under the supervision of the prescribing physician. Individual results vary. This page is informational and does not constitute medical advice.

Not a substitute for emergency care. If you are experiencing alcohol withdrawal symptoms (severe tremor, hallucinations, seizures, racing heart) call 911. For confidential 24/7 addiction support: SAMHSA Helpline 1-800-662-HELP (4357). For mental health crisis: 988.
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