Ketamine for Alcoholism and Marijuana Addiction
Backed by peer-reviewed research from Columbia University and the American Journal of Psychiatry. At-home ketamine therapy for alcohol use disorder and cannabis use disorder — prescribed by Dr. David Mahjoubi, MD, board-certified anesthesiologist and author of The Art & Science of Ketamine Medicine. First 30-day supply covered.
- 3,900+ patients since 2014
- Board-certified anesthesiologist
- HIPAA compliant
- LegitScript certified
- As seen on BBC · CNN · WebMD

If any of this sounds like you, you’re in the right place.
- You said you’d stop after one drink — and didn’t.
- You’ve tried Naltrexone, Antabuse, or Campral — and it didn’t stick.
- You’ve done AA, SMART Recovery, or rehab — and the cravings are still there.
- You’ve been smoking weed daily for years and you can’t picture life without it.
- You use cannabis to sleep, to relax, to function — and you’ve lost the off-switch.
- You know it’s affecting your relationships, your work, your health — and you still can’t stop.
- You’ve tried “white-knuckling it” and the craving always wins.
Ketamine works on the brain circuits that drive craving — not just willpower.
Alcohol and cannabis both hijack the brain’s reward system (the nucleus accumbens and prefrontal cortex) and rewire it to crave more. Ketamine is an NMDA receptor antagonist. It interrupts the consolidation of craving memories and promotes BDNF — the neuroplasticity protein that lets your brain “unlearn” addictive patterns. Combined with brief therapy, the research shows this can substantially extend abstinence.
The Research: What the Peer-Reviewed Studies Actually Show
Ketamine for alcohol and cannabis use disorder is one of the most actively researched non-FDA-approved uses of ketamine. Here are the most-cited human clinical trials.
American Journal of Psychiatry · Feb 2020
A Single Ketamine Infusion Combined With Motivational Enhancement Therapy for Alcohol Use Disorder
Dakwar E, Levin F, Hart CL, Basaraba C, Choi J, Pavlicova M, Nunes EV — Columbia University / New York State Psychiatric Institute
American Journal of Psychiatry · 2022
Adjunctive Ketamine With Relapse Prevention–Based Psychological Therapy in the Treatment of Alcohol Use Disorder (KARE Trial)
Grabski M, McAndrew A, Lawn W, et al. — University of Exeter / University College London
Journal of Substance Abuse Treatment · 20
Ketamine-Facilitated Behavioral Treatment for Cannabis Use Disorder
Azhari N, Hu H, O’Malley SS, et al.
Frontiers in Psychiatry · 2018 (Systematic Review)
Efficacy of Ketamine in the Treatment of Substance Use Disorders: A Systematic Review
Jones JL, Mateus CF, Malcolm RJ, Brady KT, Back SE — Medical University of South Carolina
Journal of Substance Use & Addiction Treatment · 2025 (Systematic Review)
Role of Ketamine in the Treatment of Substance Use Disorders
Recent systematic review of 14 studies, 551 participants
Important: Ketamine is FDA-approved as an anesthetic and (as esketamine) for treatment-resistant depression. Its use for alcohol use disorder and cannabis use disorder is considered off-label and supported by the studies above. Outcomes vary by individual.
Six Reasons People Choose NutraBrain for Alcohol or Cannabis Cravings
Most at-home ketamine programs are built for mental health. NutraBrain protocols are designed by an anesthesiologist who wrote the manual.
Targets the Craving Circuit
Ketamine acts on the NMDA receptor and modulates the reward circuitry that alcohol and cannabis hijack. It interrupts craving consolidation rather than just dulling the urge.
An Anesthesiologist, Not a Platform
Dr. Mahjoubi is a board-certified anesthesiologist — the specialty that has been using ketamine for decades. He literally wrote the physician manual on ketamine medicine. Not a rotating clinician. Not a chatbot.
Works Alongside AA, SMART Recovery, or Therapy
The strongest evidence is for ketamine plus behavioral support. Keep your group, your sponsor, your therapist — ketamine adds a tool, it doesn’t replace your recovery system.
Built for Your Pattern
Daily microdose, weekly session, or a hybrid — Dr. Mahjoubi tailors the protocol to whether you’re trying to quit completely or moderate, what you’ve already tried, and how heavy your use has been.
First Prescription On Us
Your first 30-day supply is covered. Try the protocol, meet Dr. Mahjoubi, see if your cravings actually shift — before committing.
Private. Discreet. From Home.
No clinic waiting room, no employer’s insurance trail, no medical-record fingerprint at a rehab. Just a video visit and a prescription that ships to your door.
Book Your Free Consult with Dr. Mahjoubi
Tell us a little about your situation and Dr. Mahjoubi’s team will reach out within 24 hours to schedule your consult. No credit card required.
Who NutraBrain Does NOT Treat for Addiction
NutraBrain’s at-home ketamine program is appropriate only for alcohol use disorder and cannabis use disorder. It is not a substitute for medical detox, residential treatment, or specialized addiction medicine for the following situations:
- Cocaine, methamphetamine, or other stimulant use disorder — please contact a specialist or SAMHSA (see below).
- Opioid use disorder — medication-assisted treatment with buprenorphine, methadone, or naltrexone is the evidence-based standard. Please see an addiction-medicine specialist.
- Benzodiazepine dependence — withdrawal is medically dangerous and requires supervised taper.
- Polysubstance use disorder — requires in-person, supervised care.
- Active alcohol withdrawal (tremor, sweating, nausea, hallucinations, or a history of seizures during withdrawal) — alcohol withdrawal can be fatal and requires medical detox first.
- Heavy daily drinking that has not yet been medically evaluated — Dr. Mahjoubi may require medical detox clearance from your PCP before starting ketamine.
If your situation fits any of the above, please reach out to SAMHSA’s National Helpline at 1-800-662-HELP (4357) — free, confidential, 24/7.
Why people switch to NutraBrain from other telehealth ketamine programs
Monthly cost, dosing ceiling, and medication flexibility compared.
| Provider | Monthly | Dose Ceiling | Medication Forms |
|---|---|---|---|
| NutraBrain | $69/mo | Up to 1,400 mg/week | Any form · sessions or microdose |
| Joyous | $129/mo | Low dose | Troches only |
| BetterU | ~$264/mo | Limited (9-session package) | Troches only |
| Mindbloom | ~$358/mo | Capped dose, bi-weekly | RDT + SubQ only |
| Innerwell | ~$366/mo | Up to 800 mg/session | RDT only · ~1× weekly |
| Wondermed | $399/mo | 1–2× weekly sessions | Troches only |
Pricing for other providers is based on publicly available information as of March 2026 and is subject to change. Most other programs don’t treat alcohol or cannabis use disorder at all. Actual costs vary by treatment plan, clinical assessment, dosage, frequency, and geographic location. NutraBrain Clinic is not affiliated with any companies referenced. This is not medical advice and does not guarantee clinical outcomes.
What ketamine therapy looks like for alcohol or cannabis cravings
Response varies by individual. Here’s the typical arc.
Days 1–14
Cravings Soften
Many patients report a noticeable drop in craving intensity within the first one to two weeks. Sleep often improves first — which removes one common trigger for use.
Weeks 2–6
Behavior Starts to Shift
The “automatic” pull toward the bottle or the joint weakens. Patients report it becomes easier to pause, to choose differently, to engage with their recovery support without white-knuckling it.
Months 2–6
New Patterns Stick
With therapy or recovery work alongside ketamine, many patients report sustained abstinence or significant moderation. Maintenance dosing is individualized.
From patients who've worked the program
5 Stars“Hello I’m just checking in to say this medicine seems to be a miracle to me. I can’t say enough, it really makes getting sober from alcohol, not only easier, but it makes it possible to walk into the same bars and restaurants I used to drink in without any craving for alcohol. I totally believe this medicine in conjunction with Ibogaine can very well be the cure for addiction one day. I have not used Ibogaine in over a decade, but this medicine reminds me of the very deep benefits I experienced with the Ibogaine. It is truly amazing, 40+ years of drinking with very little success with sobriety, it seems all behind me.“George F.Yelp
5 Stars“Wow, it’s been several years now and I can’t believe I never left a review (then again I had no idea they were on Yelp). Both Dr. Mahjoubi and his staff was incredibly responsive when I had any questions or concerns. I was on the program for about 6 months or so and it helped me at a time nothing else would. I went off it after to try TMS which was a total waste of time and money. My situation changed financially so I couldn’t afford to go back but I honestly felt like it was very helpful while I was in the program. Compared to other Ketamine options, I found his pricing to be reasonable for the care offered and would not hesitate to return should my finances allow.“Wayne B.Yelp
5 Stars“Dr Mahjoubi is one of the most amazing physicians I have had the honor of having help me. His caring demeanor, vast array of capacities into which he tries to place himself when relating to a patient and wealth of medical knowledge is not only impressive but palpable during consultations. If you take a second to peruse his publications its quite easy to see that his educational history is not only to be found in the formative Med School/Academic times of his life, but within the time of his practicing as well.“Zane C. Y.

You'll be treated by an anesthesiologist who wrote the book on ketamine medicine — literally.
Dr. David Mahjoubi, MD is a board-certified anesthesiologist with over 17 years in ketamine therapy. He is the sole author of The Art & Science of Ketamine Medicine — the only physician-authored ketamine treatment manual in print — and serves as President of the American Board of Ketamine Physicians.
Addiction medicine sits at the intersection of pharmacology, behavioral health, and recovery support. Dr. Mahjoubi’s anesthesiology background gives him the pharmacological depth; his framework respects the role of therapy and recovery programs in long-term outcomes. He personally evaluates and prescribes for every NutraBrain patient.
- Board-Certified Anesthesiologist
- Ketamine Prescriber Since 2014
- President, American Board of Ketamine Physicians
- Founder, Ketamine Healing Clinic of Los Angeles (2014)
- Author, The Art & Science of Ketamine Medicine
AS SEEN ON
- BBC
- CNN
- TMZ
- Netflix
- Prime
- WebMD
- NY Post
- Yahoo News
- LA Times
How the NutraBrain Program Works
1
Complete Intake + Book Consult
Book your free video consultation with Dr. David Mahjoubi.
2
Receive Medication by Mail
Your personalized prescription ships discreetly to your door. Begin treatment under Dr. Mahjoubi’s guidance.
3
Enroll in $69/mo Membership
Continue with ongoing refills and unlimited email access — or don’t. No long-term contract.
Try the first month on us.
Your first 30-day ketamine supply is covered when you book your initial consult. If after that first month your cravings haven’t budged, you don’t continue. No contracts. No auto-billing. No commitment beyond your initial consult fee.
Or call (818) 570-1640 — Jackie, our patient coordinator, can answer questions.
Common questions about ketamine for alcohol or cannabis use
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There is research suggesting ketamine may help across a range of substance use disorders, but the safety profile and treatment requirements for cocaine, methamphetamine, opioid, and benzodiazepine use disorders are very different — and frequently require in-person, supervised care or evidence-based medication-assisted treatment (like buprenorphine for opioids). At-home telehealth ketamine is not the right setting for those, so Dr. Mahjoubi does not treat them here. Please see the SAMHSA helpline link above for the right resource.
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You should not be intoxicated when you take a dose. But you don't have to be fully sober before your consult — Dr. Mahjoubi will discuss with you whether your drinking pattern is safe to taper at home or whether you need a medical detox first. If you have ever had withdrawal seizures, severe shaking, hallucinations, or sweating when you've gone without alcohol, you need medical detox before starting ketamine — alcohol withdrawal can be fatal.
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Yes — and you should. The strongest evidence is for ketamine combined with behavioral support, not ketamine alone. Many of our patients keep their sponsor, their group, and their therapist. Ketamine quiets the craving so the work you're doing in those rooms can land.
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At prescribed therapeutic doses, ketamine has a low addiction risk and does not produce physical withdrawal. NutraBrain's protocol is specifically designed to avoid tolerance and dependence. Patients with a history of ketamine misuse will be screened during the consult — that's a contraindication for this program.
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Cannabis withdrawal is uncomfortable but not medically dangerous. Many patients find that ketamine eases the irritability and sleep disruption that drive relapse during the first 1–2 weeks. Dr. Mahjoubi will discuss your specific pattern and what to expect during the consult.
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Maybe. It depends on your medical history, your withdrawal risk profile, and whether you have access to in-person medical support if needed. Dr. Mahjoubi may require clearance from your primary care physician or a medically supervised taper before starting ketamine. Be honest about your intake during the consult — under-reporting puts you at risk.
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Same framework — daily high-THC use rewires the same reward circuitry as alcohol, and many of our cannabis-use-disorder patients are heavy concentrate users. Dr. Mahjoubi tailors the protocol to your specific picture during the consult.
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Those are FDA-approved medications for alcohol use disorder with their own evidence base. Naltrexone reduces the reinforcing effect of alcohol; Antabuse creates a physical aversion; Campral works on glutamate stability. Ketamine works on a different mechanism (NMDA + neuroplasticity + craving consolidation). Some patients use ketamine in combination with one of these — Dr. Mahjoubi will discuss what's appropriate during your consult.
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NutraBrain is cash-pay. The $69/mo membership + ketamine cost is typically less than the cumulative out-of-pocket cost of a rehab program, intensive outpatient (IOP), or repeat medical encounters tied to drinking or cannabis use. We provide a superbill you can submit for possible out-of-network reimbursement.
The craving doesn't have to win every time.
The research shows ketamine + therapy substantially extends abstinence. Only 48 new patient spots are accepted per month nationwide.
No contracts. First month covered. Prescription delivered to your door in every state NutraBrain serves.
Important Medical Disclosure: Ketamine is FDA-approved as an anesthetic and (as esketamine / Spravato) for treatment-resistant depression. Its use for alcohol use disorder and cannabis use disorder is considered off-label and is supported by the peer-reviewed research cited on this page. Dr. David Mahjoubi, MD’s recommendation is for patients to be evaluated by a primary care physician (and, when relevant, an addiction medicine specialist) prior to and during ketamine therapy. Alcohol withdrawal can be medically dangerous; do not attempt rapid cessation of heavy daily alcohol use without medical supervision. Tapering of any prescribed medication should be done under the supervision of the prescribing physician. Individual results vary. This page is informational and does not constitute medical advice.